Ovarian SAHA Syndrome Is Associated With a More Insulin-Resistant Profile and Represents an Independent Risk Factor for Glucose Abnormalities in Women With PCOS

Post on November 7, 2013 by André Broussard, D.C.

Prospective Controlled Study

J Am Acad Dermatol 2013 Oct 14;[EPub Ahead of Print], M Dalamaga, E Papadavid, G Basios, V Vaggopoulos, D Rigopoulos, D Kassanos, E Trakakis

TAKE-HOME MESSAGE

  • Is ovarian SAHA syndrome (seborrhea, acne, hirsutism, and androgenic alopecia) associated with insulin resistance?
  • Of patients with polycystic ovarian syndrome, 17.7% had SAHA syndrome, which was associated with a more insulin-resistant profile.
  • It is important to diagnose SAHA syndrome early to implement monitoring of metabolic abnormalities.

ABSTRACT

Background: SAHA syndrome is characterized by the tetrad: seborrhea, acne, hirsutism, and androgenetic alopecia. No previous study has examined the prevalence of glucose abnormalities in ovarian SAHA and explored whether it may be an independent risk factor for glucose abnormalities.

Objective: In a prospective controlled study, we investigated the spectrum of glucose abnormalities in ovarian SAHA and explored whether it is associated with a more insulin-resistant profile.

Methods: In all, 316 patients with a diagnosis of polycystic ovary syndrome (PCOS) (56 with SAHA) and 102 age-matched healthy women were examined and underwent a 2-hour oral glucose tolerance test. Serum glucose homeostasis parameters, hormones, and adipokines were determined.

Results: SAHA prevalence was 17.7% in patients with PCOS and predominance of the severe PCOS phenotype. Ovarian SAHA was independently associated with a more insulin-resistant profile (higher homeostatic model assessment of insulin resistance score, lower quantitative insulin sensitivity check index [QUICKI] and MATSUDA indices, and relative hypoadiponectinemia), and represented an independent risk factor for glucose abnormalities regardless of anthropometric features, age, and PCOS phenotype.

Limitation: There was no performance of skin biopsies.

Conclusion: The prompt recognition of SAHA syndrome in women with PCOS permits an earlier diagnosis and surveillance of metabolic abnormalities, especially in Mediterranean PCOS population exhibiting a lower prevalence of glucose abnormalities.

Full Story:  http://www.practiceupdate.com/journalscan/6574
Journal Abstract:  http://www.jaad.org/article/S0190-9622(13)00965-1/abstract

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