Review · April 26, 2014
TAKE-HOME MESSAGE
- In this review and meta-analysis of 28 articles, psoriasis was reported to be associated with a 2.4-fold increase in the frequency of celiac disease markers. Based on a small number of studies, a gluten-free diet may be beneficial in celiac antibody–positive patients with psoriasis.
- Psoriasis patients have a higher prevalence of IgA AGA antibodies, which signify gluten sensitivity; however, this did not correspond to biopsy-confirmed celiac disease in patients with psoriasis. Because a gluten-free diet may benefit some patients with psoriasis and gluten sensitivity, clinicians should consider screening patients for gluten sensitivity.
– Sarah Churton, MD
ABSTRACT
Patients with psoriasis have been shown to have a higher prevalence of other autoimmune diseases including celiac disease, a condition marked by sensitivity to dietary gluten. A number of studies suggest that psoriasis and celiac disease share common genetic and inflammatory pathways. Here we review the epidemiologic association between psoriasis and celiac disease and perform a meta-analysis to determine whether patients with psoriasis more frequently harbor serologic markers of celiac disease. We also examine whether a gluten-free diet can improve psoriatic skin disease.
Journal of the American Academy of Dermatology
Diet and Psoriasis, Part II: Celiac Disease and Role of a Gluten-Free Diet
J Am Acad Dermatol 2014 Apr 26;[EPub Ahead of Print], BK Bhatia, JW Millsop, M Debbaneh, J Koo, E Linos, W Liao