These pictures show normal moles and melanomas. Most people have moles and they are almost always harmless. Although the first sign of a melanoma is often a change in a mole, it does not necessarily mean that all changes are melanomas. ABCDEs of Melanoma A = Asymmetry Melanomas are frequently asymmetrical: the shape of one half does not match the other. B = Border Melanomas frequently have uneven or irregular borders (ragged or notched edges). C = Color Melanomas often contain multiple shades of brown or black but can sometimes be mixed with white, gray, blue, or red. Some melanomas will show a loss of color in a preexisting mole or in the area surrounding the mole. D = Diameter Melanomas are often larger than 6 mm (1/4 inch) in diameter. However, with increased awareness about early detection, about 30% of melanomas are found when they are less than 6 mm in diameter. E = Evolution Any change. Melanomas typically have shown some evidence of change in the months prior to diagnosis.