Impact of serum vitamin D level on risk of bladder cancer: A systemic review and meta-analysis
Tumor Biology, 11/12/2014 Evidence Based Medicine Review Article
Liao Y, et al. – In this study, authors want to explore the impact of serum vitamin D level on risk of bladder cancer. The findings from the meta–analysis suggest an obvious protective effect of vitamin D against bladder cancer. Individuals with higher serum 25–hydroxyvitamin D levels suffer from less risk of subsequent bladder cancer.
- Vitamin D has important biological functions including modulation of the immune system and anti–cancer effects.
- There was no conclusive finding of the impact of serum vitamin D level on bladder cancer risk.
- A systemic review and meta–analysis was performed to assess the impact of serum 25–hydroxyvitamin D level on bladder cancer risk.
- The pooled relative risk (RR) with 95 % confidence interval (95%CI) was used to assess the impact of serum 25–hydroxyvitamin D level on bladder cancer risk.
- A total of 89,610 participants and 2238 bladder cancer cases were finally included into the meta–analysis.
- There was no obvious heterogeneity among those included studies (I2 =0 %).
- Meta–analysis total included studies which showed that a high serum 25–hydroxyvitamin D level could obviously decrease risk of bladder cancer (RR = 0.75, 95%CI 0.65–0.87, P < 0.001).
- In addition, the pooled RRs were not significantly changed by excluding any single study.