RESEARCH · November 26, 2014
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When mice were treated with yeast polysaccharide and potassium oxonate, their serum uric acid levels rose. This effect was inhibited by treatment with resveratrol.
Resveratrol activates Sirt1, which is involved in uric acid metabolism. In this study, treatment with resveratrol lowered serum uric acid levels and counteracted foot swelling caused by monosodium urate crystal (responsible for the inflammation in gouty arthritis) in mice.
ABSTRACT
Gouty arthritis is characterized by inflammation induced by monosodium urate crystal (MSU) deposition, which is resulted by increase of serum urate concentration. The management of gout, especially the recurrent attacks of chronic gouty arthritis, is still a problem to be resolved. In this study, we aimed to develop the preventive and therapeutic effects of resveratrol on gouty arthritis. Monosodium urate crystal (MSU) was used to induce gouty arthritis in foot pad of C57BL/6 mice. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in Kunming mice. Resveratrol was intraperitoneally injected to the mice in the treatment group. Article inflammation and serum uric acid level were investigated to estimate the effect of resveratrol in gout. Yeast polysaccharide and potassium oxonate were used to induce hyperuricemia in mice, and MSU to induce gouty arthritis. We identified that resveratrol inhibited foot swelling and inflammation-associated 99mTc uptake in gouty mice. Moreover, serum uric acid level was also decreased by resveratrol in hyperuricemia mice. This study highlighted that resveratrol might be applied to prevent the recurrent attack of gouty arthritis because of its inhibition of articular inflammation and down-regulation of serum uric acid.
Clinical Rheumatology
The Effect of Resveratrol on the Recurrent Attacks of Gouty Arthritis