Using a nested case-control design including 599 first stroke cases and 599 matched controls, researchers investigated the relation of baseline plasma zinc with the risk of the first stroke, and examined any possible effect modifiers in hypertensive patients. The study population was drawn from the China Stroke Primary Prevention Trial. The researchers noted a significantly lower risk of first hemorrhagic stroke in those with plasma zinc ≥ 106.9 μg/dL vs participants with baseline plasma zinc < 106.9 μg/dL (median). A significant inverse connection was found between plasma zinc and first hemorrhagic stroke in this study population.