Researchers performed this systematic review to determine if treatment with Coenzyme Q10 (CoQ10) can successfully improve symptoms and can ensure maintenance on statin therapy among patients with statin-associated myalgia. They analyzed relevant studies identified from MEDLINE, EMBASE and the Cochrane Library. For review, 8 studies were selected, and a meta-analysis was performed with 7 of those (with 321 patients). According to the findings of systematic review and meta-analysis, no benefit of CoQ10 supplementation was evident on statin-associated muscle pain in these patients and the adherence to statin therapy was not improved post-supplementation of CoQ10.