This study was attempted to assess whether an anti-inflammatory diet reduces disease activity in patients with rheumatoid Arthritis (RA). Researchers performed a single-blinded crossover trial including a total of 50 patients with RA. Patients were allocated randomly to an intervention diet containing a portfolio of suggested anti-inflammatory foods, or a control diet similar to the general dietary intake in Sweden, for 10 wk. Primary endpoint included change in Disease Activity Score in 28 joints-Erythrocyte Sedimentation Rate (DAS28-ESR). Changes in the components of DAS28-ESR (tender and swollen joints, ESR, and visual analog scale for general health) and DAS28-C-reactive protein were considered as secondary endpoints. The data reveal positive impacts of a proposed anti-inflammatory diet on disease activity in patients with RA. Additional studies are required to determine if this diet can cause clinically relevant improvements.