In adult patients with migraine, researchers determined the impacts of coenzyme Q10 (CoQ10), also known as ubiquinone, in reducing the severity and frequency of migraine attacks and the duration of headache in this systematic review and meta-analysis involving 371 participants. This meta-analysis included all randomized control trials contrasting CoQ10 with placebo or using it as an adjunct therapy. Cross-over designs and controlled clinical trials were not included. No statistically significant decrease in migraine headache severity was seen with CoQ10 supplementation. In minimizing the duration and frequency of migraine attacks, CoQ10 seems to have beneficial effects.