Researchers undertook this multicentric population-based case-control study to determine if ultra-processed foods and drinks intake is related to breast, colorectal, and prostate cancers. Males and females between 20-85 years of age who received diagnoses of colorectal (n = 1,852), breast (n = 1,486), or prostate cancer (n = 953) were included, as well as population-based controls (n = 3,543) frequency-matched by age, gender, and region. A higher risk of colorectal cancer was reported in relation to intake of ultra-processed foods and drinks, as shown in multiple adjusted models. No link was suggested by the corresponding odds for breast and prostate cancer. Thus, a link between intake of ultra-processed foods and drinks and colorectal cancer was shown in this study. Focusing on food processing is recommended for food policy and public health when creating dietary guidelines.