Published: Sep 29, 2013

By Cole Petrochko, Staff Writer, MedPage Today

VIENNA — Treatment with long-acting oxycodone and naloxone in fixed combination was effective at reducing restless legs syndrome (RLS) symptom severity among patients not effectively managed on other treatments, researchers reported here.

Compared with placebo at week 12, combination oxycodone and naloxone treatment offered significant improvement in International RLS Study Group Rating Scale scores by 8.15 points (95% CI 5.46-10.85, P<0.001), according to Claudia Trenkwalder, MD, of the Center of Parkinsonism and Movement Disorders in Kassel, Germany, and colleagues.

The effects of opioid therapy “were observed within week 1 and continued over the long-term” without withdrawal or addiction events, Trenkwalder said at an oral presentation during the World Congress of Neurology.

Full Story:  http://www.medpagetoday.com/MeetingCoverage/WCN/41941