Diabetic Medicine, 10/04/2016

Hansen CS, et al. – Researchers conducted this study to explore the possible relationship between vitamin D deficiency and cardiovascular autonomic neuropathy in people with diabetes. They concluded that high and low vitamin D levels were connected with cardiovascular autonomic neuropathy in people with diabetes. They added that future studies should explore this affiliation and the efficacy of treating dysvitaminosis D to prevent cardiovascular autonomic neuropathy.

Methods

•  An aggregate of 113 people with Type 1 or Type 2 diabetes [mean (interquartile range) diabetes duration 22.0 (12–31) years, mean (sd) age 56.2 (13.0) years, 58% men] underwent vitamin D (D2 and D3) assessment, and were screened for cardiovascular autonomic neuropathy utilizing 3 cardiovascular reflex tests [heart rate response to deep breathing (E/I ratio), to standing (30/15 ratio) and to the Valsalva manoeuvre] and assessment of 5-min resting heart rate and heart rate variability indices.

Results

• Researchers found an inverse U-shaped relationship between serum vitamin D level and E/I ratio, 30/15 ratio and three heart rate variability indices (P<0.05).
• Vitamin D level was non-linearly connected with cardiovascular autonomic neuropathy diagnosis (P<0.05 adjusted for age and sex).
• Linear regression models demonstrated that an expansion in vitamin D level from 25 to 50 nmol/l was connected with an increment of 3.9% (95% CI 0.1;7.9) in E/I ratio and 4.8% (95% CI 4.7;9.3) in 30/15 ratio.
• An increase from 125 to 150 nmol/l in vitamin D level was connected with a decline of 2.6% (95% CI -5.8;0.1) and 4.1% (95% CI -5.8;-0.5) in the respective outcome measures.

Journal Abstract

PubMed Reference