Men (Aged 40-49 Years) With a Single Baseline PSA Below 1.0 ng/mL Have a Very Low Long-Term Risk of Prostate Cancer

Post on November 12, 2013 by André Broussard, D.C.

Results From a Prospectively Screened Population Cohort

Urology 2013 Oct 21;[EPub Ahead of Print], CJ Weight, SP Kim, DJ Jacobson, ME McGree, RJ Karnes, J St Sauver

TAKE-HOME MESSAGE

  • In men undergoing screening as part of a prospectively followed population cohort, a single baseline PSA test < 1.0 ng/mL predicted for a very low long-term risk of prostate cancer.

ABSTRACT

Objective: To study the use of a baseline prostate-specific antigen (PSA) and digital rectal examination in men (aged 40-49 years) in predicting long-term prostate cancer risk in a prospectively followed, representative population cohort.

Patients and Methods: Since 1990, a random sample of men in Olmsted County (aged 40-49 years) has been followed up prospectively (n = 268), with biennial visits, including a urologic questionnaire, PSA screening, and physical examination. The ensuing risk of prostate cancer (CaP) was compared using survival analyses.

Results: Median follow-up was 16.3 years (interquartile range 14.0-17.3, max 19.1). For men with a baseline PSA 1.0 ng/mL had a significant risk of CaP diagnosis and should be monitored more closely.

Journal Abstract:  http://www.goldjournal.net/article/S0090-4295(13)01061-3/abstract

Comments Are Closed