May 01, 2014
TAKE-HOME MESSAGE
- In this study, the mortality risk of 12,060 adults from the NHANES III and NHANES continuous surveys was estimated according to physical activity, pharmacotherapy, and glycemic control. The results indicated that patients who had uncontrolled diabetes or who had controlled glucose levels but were physically inactive had higher all-cause mortality risk (P < .05). Researchers also noted inactive patients with type 2 diabetes had increased cardiovascular disease mortality risk regardless of glucose control (P < .05). Patients with type 2 diabetes who were physically active, treated, and achieved glycemic control had similar all-cause mortality risk as adults without diabetes.
- Investigators concluded that patients with type 2 diabetes may attain lower all-cause and cardiovascular disease mortality risk through physical activity and glycemic control.
– Lisa Parikh, MD
ABSTRACT
AIMS
This study determined the joint association between physical activity, pharmacotherapy, and HbA1c control on all-cause and cardiovascular disease (CVD) mortality risk in adults with and without type 2 diabetes (T2D).
METHODS
12,060 adults from NHANES III and NHANES continuous (1999-2002) surveys were used. Cox proportional hazards analyses were included to estimate mortality risk according to physical activity, pharmacotherapy, and glycemic control (HbA1c <7.0%) status, with physically active, treated and controlled (goal situation) as the referent.
RESULTS
Compared to the referent, adults with T2D who were uncontrolled, or controlled but physically inactive had a higher all-cause mortality risk (p<0.05). Compared to the referent, only adults with T2D who were physically inactive had a higher CVD mortality risk, regardless of treatment or control status (p<0.05). Normoglycemic adults had a similar all-cause and CVD mortality risk as the referent (p>0.05).
CONCLUSIONS
Physical activity and glycemic control are both associated with lower all-cause and CVD mortality risk in adults with T2D. Adults with T2D who are physically active, pharmacologically treated, and obtain glycemic control may attain similar mortality risk as normoglycemic adults.
Related Items
Trends in Prevalence and Control of Diabetes
Journal of Diabetes and Its Complications
All-Cause and Cardiovascular Mortality Risk in US Adults With and Without Type 2 Diabetes: Influence of Physical Activity, Pharmacological Treatment and Glycemic Control
J. Diabetes Complicat. 2014 May 01;28(3)311-335, RE Brown, MC Riddell, AK Macpherson, KL Canning, JL Kuk