The American Journal of Gastroenterology , (16 September 2014) | doi:10.1038/ajg.2014.233 A Prospective Study of the Effect of Bowel Movement Frequency, Constipation, and Laxative Use on Colorectal Cancer Risk Jessica Citronberg, Elizabeth D Kantor, John D Potter and Emily White Abstract OBJECTIVES: Constipation and laxative use have been hypothesized to increase colorectal cancer (CRC) risk, […]
Cancer Prevention Research, 09/12/2014 Clinical Article Vasudevan A, et al. – The primary objectives of this investigation are to examine whether eicosapentaenoic acid synergizes with FuOx, the backbone of colon cancer chemotherapy, and (b) whether EPA by itself or in combination with conventional chemotherapy prevents the recurrence of colon cancer via eliminating/suppressing CSCs/CSLCs. The data […]
Abstract Increasing evidence supports the contention that many malignancies, including sporadic colorectal cancer, are driven by the self-renewing, chemotherapy-resistant cancer stem/stem-like cells (CSC/CSLC), underscoring the need for improved preventive and therapeutic strategies targeting CSCs/CSLCs. Omega-3 polyunsaturated fatty acids (ω-3 PUFA), have been reported to inhibit the growth of primary tumors, but their potential as a […]
DNA Test Wins FDA, CMS Approval at Same Time Published: Aug 12, 2014 By Charles Bankhead, Staff Writer, MedPage Today WASHINGTON — The first-ever DNA-based screening test for colorectal cancer has received FDA approval and preliminary approval for Medicare coverage of the test. The Cologuard test detects hemoglobin and mutant DNA in cells sloughed into […]
Roxanne Nelson August 11, 2014 (Corrected Aug. 12, 2014) The US Food and Drug Administration (FDA) today approved Cologuard (Exact Sciences Corporation), a stool-based colorectal cancer (CRC) in vitro diagnostic device. Cologuard analyzes stool specimens to detect hemoglobin, multiple DNA methylation and mutational markers, and the total amount of human DNA contained in cells that are shed […]
Benefits Add Up for Regular Aspirin Use Published: Aug 5, 2014 | Updated: Aug 6, 2014 Discussant: Joseph Chao, MD. Average-risk adults in the general population who used aspirin regularly for at least 5 years had a lower risk of cancer, myocardial infarction (MI), stroke, and premature death, according to a comprehensive review of potential […]
Story Source BY JOHN UPTON • July 22, 2014 • 10:51 AM Reduced carb intake among mice protected them from colon cancer. • Colorectal cancer is a scourge of modern times, killing 50,000 Americans every year. It’s responsible for a heavier death toll than any other cancer besides lung cancer and, when it comes to women, breast cancer. And […]
Date: July 17, 2014 Source: Cell Press Summary: Colorectal cancer has been linked to carbohydrate-rich western diets, but the underlying mechanisms have been unclear. A new study shows that gut microbes metabolize carbohydrates in the diet, causing intestinal cells to proliferate and form tumors in mice that are genetically predisposed to colorectal cancer. Treatment with […]
Calcium, Vitamin D, Dairy Products, and Mortality Among Survivors of CRC Practice Update RESEARCH · June 23, 2014 Story Source TAKE-HOME MESSAGE Findings from the prospective CPS-II Nutrition cohort are presented, demonstrating that higher intake of calcium, vitamin D, and dairy products were all associated with lower incidence of colorectal cancer. Post-diagnosis, calcium and milk […]
Published: Jun 10, 2014 | Updated: Jun 11, 2014 By Charles Bankhead, Staff Writer, MedPage Today Action Points Note that this review specifies suggested dietary guidance in which evidence of a dietary influence on cancer risk is substantial, but not necessarily conclusive. The review provides guidance based upon compelling evidence for cancer risk associated with […]
MedPageToday.com Vitamin D Blog: Cancer Risk in IBD Published: Jul 8, 2014 By Ashwin Ananthakrishnan, MBBS, MPH , Massachusetts General Hospital Story Source In this Guest Blog, Ashwin N. Ananthakrishnan, MBBS, MPH, a gastroenterologist at Massachusetts General Hospital in Boston, discusses his recent study on vitamin D and its relationship with cancer in patients with […]
A systematic review and meta-analysis Annals of Oncology, 03/25/2014 Review Article Schmid D, et al. – Using prospective studies published through June 2013, the authors conducted a systematic review and random–effects meta–analysis of pre– and post–diagnosis physical activity in relation to total and cancer mortality among breast or colorectal cancer survivors. Physical activity performed before or after […]
A systematic review and meta-analysis Annals of Oncology, 03/25/2014 Review Article Schmid D, et al. – Using prospective studies published through June 2013, the authors conducted a systematic review and random–effects meta–analysis of pre– and post–diagnosis physical activity in relation to total and cancer mortality among breast or colorectal cancer survivors. Physical activity performed before […]
New England Journal of Medicine, 03/21/2014 Evidence Based Medicine Clinical Article Imperiale TF, et al. – An accurate, noninvasive test could improve the effectiveness of colorectal–cancer screening. In asymptomatic persons at average risk for colorectal cancer, multitarget stool DNA testing detected significantly more cancers than did FIT but had more false positive results. Methods Authors compared a […]
by Charles Bankhead Staff Writer, MedPage Today March 19, 2014 A stool DNA test detected significantly more colon cancers in average-risk patients as compared with a conventional fecal immunochemical test (FIT), a large prospective clinical study showed. The DNA test detected 92.3% of colorectal cancers versus 73.8% for FIT in a study involving almost 10,000 […]
Wednesday, 19 Mar 2014 08:26 AM A novel colon cancer test from Exact Sciences Corp. (EXAS) and the Mayo Clinic using the DNA of specimens that patients collect at home detects more tumors than methods focusing on blood in the stool, a study found. The research released Tuesday by the New England Journal of Medicine […]
European Journal of Cancer, 03/04/2014 Evidence Based Medicine Review Article Clinical Article PubMed Reference Maalmi H, et al. – This studya ims to estimate the association between serum 25–hydroxyvitamin D (25(OH)D) levels and survival among colorectal and breast cancer patients. Higher 25(OH)D levels (>75nmol/L) were associated with significantly reduced mortality in patients with colorectal and breast cancer. […]
IMNG Medical Media, 2014 Feb 03, S Freeman February 04, 2014 Full Story Fecal immunochemical tests have an overall diagnostic accuracy of 95% for the detection of colorectal cancer, according to the results of a meta-analysis just published in the Annals of Internal Medicine. The tests, which have already begun to replace the fecal occult blood […]
Nutr Cancer. 2014;66(1):128-39. doi: 10.1080/01635581.2014.852686. Epub 2013 Dec 16. Tse G, Eslick GD. Abstract Evidence shows cruciferous vegetables exhibit chemoprotective properties, commonly attributed to their rich source of isothiocyanates. However, epidemiological data examining the association between cruciferous vegetable intake and colorectal neoplasms have been inconclusive. This meta-analysis examines the epidemiological evidence to characterize the association […]
Maturitas. 2014 Mar;77(3):202-8. doi: 10.1016/j.maturitas.2013.11.010. Epub 2013 Dec 11. Baena Ruiz R, Salinas Hernández P. Abstract BACKGROUND: Diet represents 30-35% of risk factors that contribute to the onset of cancer. Some foods and dietary patterns have been linked to the risk of various cancers. However epidemiological available data are not consistent for many foods and […]