Mechanisms

How Does A Chiropractic Treatment Work? [Video]

Apr 16, 2021 Gregory D. Cramer, DC, PhD is the Dean of the Department of Research and a Professor of Research and Basic Sciences at National University of Health Sciences, and he presents a video where he reviews some of the science behind what happens with a chiropractic adjustment. The video is 58 minutes, 11 seconds, so […]

Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain

Eur J Pain. 2021 Aug;25(7):1429-1448. doi: 10.1002/ejp.1773. Epub 2021 Apr 15. Carlos Gevers-Montoro Abstract Together, neck pain and back pain are the first cause of disability worldwide, accounting for more than 10% of the total years lived with disability. In this context, chiropractic care provides a safe and effective option for the management of a […]

How Spinal Adjusting May Affect The Neuroendocrine System – Video

How spinal adjusting may affect the neuroendocrine system – interview with researcher Dr. Kesava Some patient report better sleep, improved digestion, immune system improvements, reduced stress, reduced inflammation, and overall well-being following their chiropractic or osteopathic spinal manipulation adjustments. Dr. Pete Angerilli, chiropractor interviews researcher and clinician Dr. Kesava Kovanur Sampath discussing some of his […]

Endocannabinoids Release After Osteopathic Manipulative Treatment. A Brief Review

J Complement Integr Med. 2020 Jun 18;/j/jcim.ahead-of-print/jcim-2020-0013/jcim-2020-0013.xml. doi: 10.1515/jcim-2020-0013. Andrea Buscemi Abstract Objectives Since 70’s, scientific research has analyzed how many acute and chronic issues can affect body systems. In case of depression, chronic pain and overtraining, centrals and peripherals systems act to manage and maintain body adaptations. The aim of this study is to […]

The effect of spinal manipulation on brain neurometabolites in chronic nonspecific low back pain patients: a randomized clinical trial

Ir J Med Sci. 2020 May;189(2):543-550. doi: 10.1007/s11845-019-02140-2. Epub 2019 Nov 26. Daryoush Didehdar PMID: 31773541 DOI: 10.1007/s11845-019-02140-2 Abstract Background: In patients with chronic nonspecific low back pain (NCLBP), brain function changes due to the neuroplastic changes in different regions. Aim: The current study aimed to evaluate the brain metabolite changes after spinal manipulation, using […]

Neurophysiological Effects of High Velocity and Low Amplitude Spinal Manipulation in Symptomatic and Asymptomatic Humans

A Systematic Literature Review Wirth, Brigitte PT, PhD Spine: August 1, 2019 – Volume 44 – Issue 15 – p E914-E926 doi: 10.1097/BRS.0000000000003013 Study Design. Systematic review. Objective. To summarize the evidence of neurophysiological effects of spinal manipulative therapy (SMT) with a high velocity low amplitude thrust (HVLA-SMT) in asymptomatic and symptomatic humans. Summary of […]

Diverse Role of Biological Plasticity in Low Back Pain and Its Impact on Sensorimotor Control of the Spine

Published: Journal of Orthopaedic & Sports Physical Therapy, 2019 Volume:49 Issue:6 Pages:389–401 DOI: 10.2519/jospt.2019.8716 Synopsis Pain is complex. It is no longer acceptable to consider pain solely as a peripheral phenomenon involving activation of nociceptive neurons. The contemporary understanding of pain involves consideration of different underlying pain mechanisms and an increasing awareness of plasticity in […]

Spinal manipulation therapy: is it all about the brain? A current review of the neurophysiological effects of manipulation

Journal of Integrative Medicine Available online 9 May 2019 GilesGyer Abstract Spinal manipulation has been an effective intervention for the management of various musculoskeletal disorders. However, the mechanisms underlying the pain modulatory effects of spinal manipulation remain elusive. Although both biomechanical and neurophysiological phenomena have been thought to play a role in the observed clinical […]

Spinal Manipulative Therapy Effects in Autonomic Regulation and Exercise Performance in Recreational Healthy Athletes

A Randomized Controlled Trial Valenzuela, Pedro L., MSc∗,†; Pancorbo, Sara, MChiro‡; Lucia, Alejandro, MD, PhD§; Germain, Francisco, MD, PhD∗ Spine: May 1, 2019 – Volume 44 – Issue 9 – p 609-614 doi: 10.1097/BRS.0000000000002908 Study Design. A randomized, double blind, parallel groups, sham-controlled trial. Objective. The aim of this study was to analyze the acute […]

Decreased Neurologic Pain Signature Activation Following Thoracic Spine Manipulation in Healthy Volunteers

The Journal of Pain Volume 20, Issue 4, Supplement, April 2019, Page S69 K.Webe Spinal manipulation (SM) is commonly used when managing patients with neck and back pain. The rationale regarding the use of SM has long been supported by the clinical opinion that a mechanical effect on the spine leads to therapeutic mechanical changes […]

Increased Salience Network Connectivity following Spinal Manipulative Therapy is Associated with Reduced Pain in Chronic Low Back Pain Patients

The Journal of Pain K. Isenburg, M. Loggia April 2019 Volume 20, Issue 4, Supplement, Page S42 Abstract Chronic low back pain (cLBP) has been associated with maladaptive brain plasticity, and non-pharmacological therapies such as Spinal Manipulative Therapy (SMT) have shown promise in reducing pain and modifying intrinsic brain physiology. However, more translational research is […]

Effect of spinal manipulative therapy on mechanical pain sensitivity in patients with chronic nonspecific low back pain: a pilot randomized, controlled trial

Journal of Manual & Manipulative Therapy Bryan M. Bond Published online: 05 Mar 2019 ABSTRACT Objectives: The long-term goal of our study is to improve the understanding of the biological mechanisms associated with spinal manipulative therapy (SMT) in low back pain. Methods: This project involved a pilot randomized, blinded clinical trial (ClinicalTrials.gov registration number NCT03078114) […]

Intervertebral kinematics of the cervical spine before, during, and after high-velocity low-amplitude manipulation

The Spine Journal Volume 18, Issue 12, December 2018, Pages 2333-2342 William J.Anderst PhD Abstract Background context Neck pain is one of the most commonly reported symptoms in primary care settings, and a major contributor to health-care costs. Cervical manipulation is a common and clinically effective intervention for neck pain. However, the in vivo biomechanics […]

Brain Mechanisms of Anticipated Painful Movements and Their Modulation by Manual Therapy in Chronic Low Back Pain

J Pain. 2018 Nov;19(11):1352-1365. doi: 10.1016/j.jpain.2018.05.012. Epub 2018 Jul 3. Ellingsen DM Abstract Heightened anticipation and fear of movement-related pain has been linked to detrimental fear-avoidance behavior in chronic low back pain (cLBP). Spinal manipulative therapy (SMT) has been proposed to work partly by exposing patients to nonharmful but forceful mobilization of the painful joint, […]

In Vivo Human Facet Joint Gapping During Cervical Spine Manipulation

1William Anderst PhD, 1Tom Gale MS, 2Kris Gongaware DC and 2Michael Schneider DC, PhD 1Department of Orthopaedic Surgery and 2Department of Physical Therapy University of Pittsburgh, Pittsburgh, PA, USA (bdl.pitt.edu) This study demonstrates our ability to characterize facet gapping, believed to be one of the key mechanical events of spinal manipulation. Cervical manipulation induces supraphysiologic […]

Short-term increase in discs’ apparent diffusion is associated with pain and mobility improvements after spinal mobilization for low back pain – Full Text

Sci Rep. 2018; 8: 8281. Published online 2018 May 29. doi:  10.1038/s41598-018-26697-7 PMCID: PMC5974269 PMID: 29844484 Paul Thiry,1 François Reumont,#1 Jean-Michel Brismée,2 and Frédéric Dierick#3,4 Author information ► Article notes ► Copyright and License information ► Disclaimer Go to: Abstract Pain perception, trunk mobility and apparent diffusion coefficient (ADC) within all lumbar intervertebral discs (IVDs) were collected before and shortly after posterior-to-anterior (PA) mobilizations in 16 adults with acute […]

Subclinical recurrent neck pain and its treatment impacts motor training-induced plasticity of the cerebellum and motor cortex

PLoS One. 2018; 13(2): e0193413. Published online 2018 Feb 28. doi: 10.1371/journal.pone.0193413 PMCID: PMC5831387 PMID: 29489878 Julianne K. Baarbé Abstract The cerebellum processes pain inputs and is important for motor learning. Yet, how the cerebellum interacts with the motor cortex in individuals with recurrent pain is not clear. Functional connectivity between the cerebellum and motor […]

Neural Responses to Physical Characteristics of a High-velocity, Low-amplitude Spinal Manipulation: Effect of Thrust Direction

Reed, William R. DC, PhD∗; Long, Cynthia R. PhD∗; Kawchuk, Gregory N. DC, PhD†; Sozio, Randall S. BS∗; Pickar, Joel G. DC, PhD∗Author Information SPINE: January 1, 2018 – Volume 43 – Issue 1 – p 1-9 doi: 10.1097/BRS.0000000000001344 Abstract Study Design. Electrophysiological recordings were obtained from proprioceptors in deep lumbar paraspinal muscles of anesthetized […]

The mechanism of back pain relief by spinal manipulation relies on decreased temporal summation of pain

Neuroscience. 2017 May 4;349:220-228. doi: 10.1016/j.neuroscience.2017.03.006. Epub 2017 Mar 11. Randoll C Abstract The aim of the present study was to determine whether thoracic spinal manipulation (SM) decreases temporal summation of back pain. The study comprised two controlled experiments including 16 and 15 healthy participants, respectively. Each study included six sessions during which painful or […]

Changes in biochemical markers following spinal manipulation-a systematic review and meta-analysis

Musculoskeletal Science & Practice June 2017  Volume 29, Pages 120–131 Kesava Kovanur-Sampath, M.Ost Highlights •Various biochemical markers such as substance-P, neurotensin, interleukins and cortisol modulate pain and inflammation. •Spinal manipulation increases substance-P, neurotensin, oxytocin and can alter various biochemical marker. •Spinal manipulation therefore may play an important role in pain and or inflammatory disorders. •Future RCTs […]