CATHERINE GUTHRIE · MARCH 2015 Your intestines are home to a great deal of your digestive system, nervous system, and immune system. Here’s how to keep them healthy. Modern life is hard on your gut. Your entire digestive tract can be affected by stress, processed foods, alcohol, medications, and bacteria. All that chronic irritation can lead to inflammation and, […]
Michael O’Riordan February 24, 2015 GENTOFTE, DENMARK — Patients receiving antithrombotic therapy following an MI who take a nonsteroidal anti-inflammatory drug (NSAID) are at an increased risk of bleeding and an increased risk of cardiovascular death, nonfatal recurrent MI, and stroke, according to the results of a new Danish observational study[1]. The increased risk of bleeding and […]
Megan Brooks DisclosuresJanuary 09, 2015 In a drug safety communication issued today, the US Food and Drug Administration (FDA) says it is aware of recent reports “questioning” the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy, but that it lacks adequate studies to change current recommendations. The benefits and risks of using prescription […]
Ricki Lewis, PhD December 19, 2014 Story Source Nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against skin cancer, according to a study published online December 18 in the Journal of Investigative Dermatology. NSAID use has been associated with lowered risk for colon, lung, breast, and prostate cancers, but evidence for preventing skin cancer has been inconclusive. Chiho Muranushi, PhD, from the […]
Ricki Lewis, PhD Story Source December 19, 2014 Nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against skin cancer, according to a study published online December 18 in the Journal of Investigative Dermatology. NSAID use has been associated with lowered risk for colon, lung, breast, and prostate cancers, but evidence for preventing skin cancer has been inconclusive. Chiho Muranushi, PhD, from the […]
Frontline Medical News, 2014 Nov 17, A Karon Story Source Taking nonsteroidal anti-inflammatory drugs for 14 days more than doubled the risk of serious bleeding in patients with atrial fibrillation, and it increased the risk of thromboembolism by 36%, according to a report published online Nov. 17 in Annals of Internal Medicine. Risk of serious […]
November 26, 2014 Annals of Internal Medicine TAKE-HOME MESSAGE The authors of this observational cohort study of over 150,000 Danish patients with atrial fibrillation (AF) hospitalized from 1997 to 2011 examined the risk for serious bleeding and thromboembolism associated with NSAID and antithrombotic therapy. At 3 months, the absolute risk difference for serious bleeding in […]
Frontline Medical News, 2014 Nov 17, A Karon Taking nonsteroidal anti-inflammatory drugs for 14 days more than doubled the risk of serious bleeding in patients with atrial fibrillation, and it increased the risk of thromboembolism by 36%, according to a report published online Nov. 17 in Annals of Internal Medicine. Risk of serious bleeding and […]
Use of often prescribed drugs against arthritis and pain increases the risk of dying from a stroke. This is the conclusion of a major new registry study involving more than 100,000 patients. 2014.11.13 | LOTTE FISKER JØRGENSEN It is older versions of COX-2 inhibitors, which are now linked to increased risk of dying from a […]
Jenni Laidman October 27, 2014 Ibuprofen proved just as effective as morphine for pain control in children with uncomplicated fractures, and it brought on significantly fewer adverse effects, according to a study published online October 27 in the Canadian Medical Association Journal. In a parallel-group, randomized, blinded superiority trial, Naveen Poonai, MD, from the Division of […]
Megan Brooks October 21, 2014 Nonsteroidal anti-inflammatory drugs (NSAIDs) may help ease depressive symptoms, new research suggests. Results of a meta-analysis show that the adjunctive use of NSAIDs was associated with improved antidepressant treatment response without an increased risk for adverse effects. In particular, add-on treatment with celecoxib (Celebrex, GD Searle LLC) improved antidepressant effects, […]
Larry Hand September 25, 2014 Story Source Nonsteroidal anti-inflammatory drugs (NSAIDs) may almost double the risk for venous thromboembolism (VTE), including deep venous thrombosis and pulmonary embolism, according to an article published online September 24 in Rheumatology. “[T]he results of our meta-analysis demonstrate a statistically significantly increased VTE risk among NSAID users. Physicians should be […]
Gwen M.C. Masclee Gastroenterology Volume 147, Issue 4, Pages 784–792.e9, October 2014 Background & Aims Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB […]
DrPerlmutter.com As I have discussed on many occasions in this forum, the process of inflammation is a cornerstone of virtually any degenerative condition in the human experience. This includes diseases like cancer, diabetes, coronary artery disease, Alzheimer’s disease, Parkinson’s disease, stroke, arthritis, and so many more. So it’s really important that we take a step […]
PracticeUpdate.com RESEARCH · July 08, 2014 TAKE-HOME MESSAGE This study investigated the association of regular use of NSAIDs with increased risk for cardiovascular events in postmenopausal women. Using data from the Women’s Health Initiative, investigators identified 53,142 women as regular NSAID users. Overall, NSAID use was associated with an increased hazard for cardiovascular events compared […]
JAMA Intern Med. 2014 Jun;174(6):947-53. doi: 10.1001/jamainternmed.2014.946. Davidson BL1, Verheijen S2, Lensing AW3, Gebel M4, Brighton TA5, Lyons RM6, Rehm J7, Prins MH8. Abstract IMPORTANCE: Combined anticoagulant and aspirin therapy is associated with increased bleeding risk in patients with atrial fibrillation, but the bleeding risk of combined use of anticoagulant and nonsteroidal anti-inflammatory drugs (NSAIDs) […]
Nonsteroidal Anti-Inflammatory Drugs Versus Corticosteroid for Treatment of Shoulder Pain: A Systematic Review and Meta-Analysis Xiao-Qing Zheng, MSc∗, Ke Li, MSc∗, You-Dong Wei, MD, PhD∗, Hong-Tao Tie, MSc, Xiao-Yan Yi, MSc, Wei Huang, MD, PhDemail ∗Zheng, Li, and Wei contributed equally to this work. Published Online: May 16, 2014 Objective To compare the treatment efficacy […]
Research · April 29, 2014 TAKE-HOME MESSAGE This analysis of 15 case-control studies (n = 393,268) and 4 cohort studies found an increased risk of upper GI bleeding with selective serotonin reuptake inhibitors (SSRIs; OR, 1.66; 95% CI, 1.44–1.92). The addition of NSAIDs further increased this risk (OR, 4.25; 95% CI, 2.82–6.42). SSRIs modestly increase […]
Anne‐Marie Schjerning Olsen First published: 01 April 2014 https://doi.org/10.1111/bcpt.12243 Abstract This MiniReview describes the present evidence for the relationship between cardiovascular risk and use of non‐steroidal anti‐inflammatory drugs (NSAIDs) with special focus using Danish register‐based data. NSAIDs are among the most widely used drugs worldwide and mainly used for management of pain and inflammatory conditions. […]
Marlene Busko April 15, 2014 SEATTLE, WA — Patients receiving an anticoagulant for deep vein thrombosis (DVT) or pulmonary embolism (PE) who take a nonsteroidal anti-inflammatory drug (NSAID) or aspirin for pain or headache, even for a few days, are at heightened risk for a major bleed, according to a new study published online April […]