Research · April 14, 2014 TAKE-HOME MESSAGE This study estimated the bleeding risk when the use of anticoagulant therapy (rivaroxaban or enoxaparin–vitamin K antagonist) was combined with either an NSAID or aspirin therapy in patients with VTE enrolled in clinical trials from 2007 to 2009. Clinically relevant bleeding was higher with combined use compared with anticoagulant use […]
Published: Apr 8, 2014 By Todd Neale, Senior Staff Writer, MedPage Today Full Story Journal Full Text Article Action Points Use of NSAIDs for 15 to 30 days was associated with an increased risk of atrial fibrillation compared with never-use. Additionally, recent use (within the prior 30 days but no current use) was associated with […]
By Carole Alison Chrvala, PhD Reviewed by Philip Green, MD, Assistant in Clinical Medicine, Division of Cardiology, Department of Medicine, Columbia University Medical Center, NY Take Note Results from case-control studies suggest that nonselective NSAIDs and COX-2 inhibitors are associated with an increased risk of atrial fibrillation, with the highest risk evident for new and […]
Published: Feb 11, 2014 By John Gever, Deputy Managing Editor, MedPage Toda Full Story In 16-9 vote, the FDA advisory committee assessing NSAID safety said the warning label on naproxen should not be changed to suggest it has a better cardiovascular risk profile than other drugs in this class. Those voting “No” on the question […]
Published: Feb 9, 2014 | Updated: Feb 9, 2014 By Todd Neale, Senior Staff Writer, MedPage Today Full Story Two FDA advisory committees will meet Monday and Tuesday to consider the significance of recent evidence surrounding the cardiovascular risks of nonsteroidal anti-inflammatory drugs (NSAIDs), including studies pointing to lower risks with naproxen. The FDA put […]
Results of a large population-based study in randomly selected Dutch inhabitants Tielemans MM, et al. Int J Clin Pract. 2014 Feb 6. doi: 10.1111/ijcp.12346. [Epub ahead of print] Affiliation Abstract AIM: Non-steroidal anti-inflammatory drug (NSAID) use is widespread and associated with gastrointestinal symptoms and complications. The aims of this study were to assess (i) gastrointestinal […]
FDA: Naproxen May Pose Lower CV Risk IMNG Medical Media, 2014 Jan 29, A Ault February 03, 2014 Full Story The Food and Drug Administration says that the nonsteroidal anti-inflammatory drug naproxen may carry a lower risk of cardiovascular thromboembolic events than that of other selective or nonselective NSAIDs. The agency presented evidence for that […]
By Carole Alison Chrvala, PhD Take Note Results from case-control studies suggest that nonselective NSAIDs and COX-2 inhibitors are associated with an increased risk of atrial fibrillation, with the highest risk evident for new and long-term users, particularly older persons and those with a history of chronic kidney disease. This association has important clinical implications […]
Practical Pain Management Volume 13, Issue #10 November/December 2013 Full Story: http://www.practicalpainmanagement.com/treatments/pharmacological/opioids/ask-expert-do-nsaids-cause-more-deaths-opioids Question: I have recently read a lot on Twitter that NSAIDs cause more deaths than opioids. Can you clarify if that is true? Answer: Balancing the benefits of well-controlled pain with the risks of analgesic use is complicated and often challenging for health […]
Alzheimers Dement 2013 Nov 01;9(6)724-732, KR Obermann, JC Morris, CM Roe Research · December 19, 2013 Practice Update Website Story: http://www.practiceupdate.com/journalscan/7193 Journal Abstract: http://www.alzheimersanddementia.com/article/S1552-5260(12)02574-5/abstract TAKE-HOME MESSAGE Results of this exploratory analysis of 100 drugs showed that common medications used by older adults, 10% in this study, are associated with increases or decreases in cognitive performance. […]
Alzheimers Dement 2013 Nov 01;9(6)724-732, KR Obermann, JC Morris, CM Roe Research · December 19, 2013 Full Story: http://www.practiceupdate.com/journalscan/7193 Journal Abstract: http://www.alzheimersanddementia.com/article/S1552-5260(12)02574-5/abstract TAKE-HOME MESSAGE Results of this exploratory analysis of 100 drugs showed that common medications used by older adults, 10% in this study, are associated with increases or decreases in cognitive performance. Further studies […]
(Here’s more on Vitamin B6 on this site: https://www.integrative-archives.com/category/nutrition/vitamin-b6/) Chang HY,et al. Am J Clin Nutr. 2013 Dec;98(6):1440-9. doi: 10.3945/ajcn.113.064477. Epub 2013 Oct 23. Abstract BACKGROUND: A low circulating vitamin B-6 concentration, which is an independent risk factor for cardiovascular disease, is commonly seen in human inflammation. OBJECTIVE: We investigated whether cyclooxygenase inhibitors alter vitamin […]
IMNG Medical Media, 2013 Oct 17, JO Ebbert Full Story: http://www.practiceupdate.com/news/3596 ’Tis the season to be coughing. The most common condition we are seeing and will be seeing in the coming months is bronchitis. Bronchitis is a self-limited inflammation of the bronchi due to upper airway infection (i.e., cough without pneumonia), which is most commonly […]
Commonly used pain medications increase the risk of exacerbations of Crohn’s disease, judging from the findings of a prospective cohort study of nearly 800 patients with inflammatory bowel disease initially in remission.
J Appl Physiol (1985). 2013 Sep;115(6):892-9. doi: 10.1152/japplphysiol.00053.2013. Epub 2013 Jul 18. Bailey Su PMID: 23869068 PMCID: PMC3764618 DOI: 10.1152/japplphysiol.00053.2013 Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established. However, the effects of NSAID therapy on healing of skeletal […]
Susan Jeffrey May 30, 2013 A new meta-analysis looking at the vascular and gastrointestinal effects of nonsteroidal anti-inflammatory drugs (NSAIDs) — including selective cyclooxygenase-2 [COX-2] inhibitors, also known as coxibs, as well as traditional NSAIDs such as diclofenac and ibuprofen — shows that the vascular risks associated with high-dose diclofenac and possibly ibuprofen are similar […]
Published: May 30, 2013 | Updated: May 30, 2013 By Michael Smith , North American Correspondent, MedPage Today Action Points In this large meta-analysis diclofenac, ibuprofen, and coxibs all significantly increased major coronary events. Naproxen did not significantly increase major vascular events, but heart failure risk was roughly doubled by all NSAIDs. High doses of […]
By Carole Alison Chrvala, PhD Reviewed by Philip Green, MD, Assistant in Clinical Medicine, Division of Cardiology, Department of Medicine, Columbia University Medical Center, NY Take Note Results from case-control studies suggest that nonselective NSAIDs and COX-2 inhibitors are associated with an increased risk of atrial fibrillation, with the highest risk evident for new and […]
Nonsteroidal anti-inflammatory drugs, corticosteroid, or other injections: a systematic review The term subacromial impingement syndrome (SIS) encompasses a wide range of disorders, including rotator cuff syndrome, tendinopathy of the various rotator cuff tendons and bursitis in the shoulder region. The prescription of analgesics (often NSAIDs) and corticosteroid injections is common in primary care. This systematic […]