Tumor Necrosis Factor Alpha (TNFα)

Effects of spinal manipulative therapy on inflammatory mediators in patients with non-specific low back pain: a non-randomized controlled clinical trial

Chiropr Man Therap. 2021 Jan 8;29(1):3. doi: 10.1186/s12998-020-00357-y. Julita A Teodorczyk-Injeyan Abstract Background: The inflammatory profiles of patients with acute and chronic nonspecific low back pain (LBP) patients are distinct. Spinal manipulative therapy (SMT) has been shown to modulate the production of nociceptive chemokines differently in these patient cohorts. The present study further investigates the […]

Systemic Inflammatory Markers in Neck Pain: A Systematic Review With Meta-Analysis

Eur J Pain 2020 Jul 3. doi: 10.1002/ejp.1630. Online ahead of print. S F Farrell Abstract Background and objective: Mechanisms underpinning symptoms in non-traumatic neck pain (NTNP) and whiplash-associated disorder (WAD) are not comprehensively understood. There is emerging evidence of systemic inflammation in musculoskeletal pain conditions, including neck and back pain. The aim of this […]

Non-specific Low Back Pain: Inflammatory Profiles of Patients with Acute and Chronic Pain.

Clin J Pain. 2019 Jul 5. doi: 10.1097/AJP.0000000000000745. [Epub ahead of print] Teodorczyk-Injeyan JA1, Triano JJ1, Injeyan HS2. Abstract BACKGROUND: The pathogenesis of low back pain (LBP) remains unclear. However, recent studies suggest that the inflammatory response may be inherent in spinal pain. PURPOSE: To discern inflammatory profiles in patients with non-specific acute and chronic […]

Effect of Moderate-Intensity Exercise on Inflammatory Markers Among Postmenopausal Women

J Phys Act Health. 2017 Jun;14(6):479-485. doi: 10.1123/jpah.2016-0319. Epub 2017 Mar 2. Chagas EFB, Bonfim MR, Turi BC, Brondino NCM, Monteiro HL. Abstract BACKGROUND: Declines in ovarian function in postmenopausal women may contribute to increase inflammatory cytokines, which can lead to chronic diseases. However, studies have shown that exercise interventions are important to manage inflammatory conditions. Thus, the objective of […]

Mindfulness meditation lowers stress hormone and decreases inflammation in body, scientists find

Sarah Knapton 24 JANUARY 2017 Mindfulness meditation, the practice of paying more attention to the present moment, helps lower stress hormones and decreases inflammation in the body, scientists have proven for the first time. The training has been growing in popularity in recent years, with the NHS recommending mindfulness as a way to reduce stress and […]

Exercise …20 minutes can act as anti-inflammatory

One moderate exercise session has a cellular response that may help suppress inflammation in the body Date: January 12, 2017 Source: University of California – San Diego Summary: It’s well know that regular physical activity has health benefits, including weight control, strengthening the heart, bones and muscles and reducing the risk of certain diseases. Recently, […]

Functions of Coenzyme Q10 Supplementation on Liver Enzymes, Markers of Systemic Inflammation, and Adipokines in Patients Affected by Nonalcoholic Fatty Liver Disease: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial.

J Am Coll Nutr. 2016 May-Jun;35(4):346-53. doi: 10.1080/07315724.2015.1021057. Epub 2015 Jul 9. Farsi F1, Mohammadshahi M1, Alavinejad P2, Rezazadeh A3, Zarei M4, Engali KA5. Abstract BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disorder related to inflammation. Coenzyme Q10 (CoQ10) is a natural compound that has recently been considered as an anti-inflammatory factor. […]

Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain: Data From the Back Complaints in the Elders (BACE)-Brazil Study

Spine: February 2016 – Volume 41 – Issue 3 – p 197–203 doi: 10.1097/BRS.0000000000001214 de Queiroz, Bárbara Zille PhD Abstract Study Design. Cross-sectional study with subsample of elderly women with acute low back pain (LBP), from Back Complaints in the Elders-Brazil (BACE-Brazil) Objective. To investigate the association between plasma levels of mediators of inflammation (interleukin-1 […]

Elevated levels of tumor necrosis factor-α and TNFR1 in recurrent herniated lumbar discs correlate with chronicity of postoperative sciatic pain

The Spine Journal Volume 16, Issue 2, February 2016, Pages 243–251 Pablo Andrade, MD, PhD Abstract Background Context Sciatica is a condition characterized by radicular pain that can be secondary to a lumbar disc herniation (LDH). More than 10% of patients report persistent pain after surgery. The underlying mechanisms of postoperative sciatica remain unclear. There […]

Anti-TNF Drugs Tied to Risk for Demyelinating Diseases

Diana Swift October 07, 2015 Findings from a Danish population-based study suggest a twofold increased relative risk for central demyelinating diseases in patients with inflammatory bowel disease (IBD) who receive tumor necrosis factor (TNF) inhibitors. “If true, the observed association could either be attributed to the unmasking of a latent demyelinating disease or to the […]

Inflammatory Back Pain Linked With Bone Loss

09.26.2015 Anti-TNF and NSAID therapies have protective effects by Diana Swift Contributing Writer More than four in 10 patients having inflammatory back pain suggestive of early axial spondyloarthritis (SpA) and followed for 2 years experienced bone loss in the lumbar spine and hip, according to findings published in Rheumatology. Furthermore, even a short duration of […]

Efficacy and Safety of White Willow Bark

Phytother Res. 2015 May 22. doi: 10.1002/ptr.5377. [Epub ahead of print] Efficacy and Safety of White Willow Bark (Salix alba) Extracts. Shara M, Stohs SJ. Abstract Willow bark extract has been used for thousands of years as an anti-inflammatory, antipyretic, and analgesic. In spite of its long history of use, relatively few human and animal […]

Adding high dose vitamin D to analgesic regimens helps patients with musculoskeletal pain

Lupus. 2015 Apr;24(4-5):483-9. doi: 10.1177/0961203314558676. A randomized double-blind placebo-controlled study adding high dose vitamin D to analgesic regimens in patients with musculoskeletal pain. Gendelman O1, Itzhaki D2, Makarov S3, Bennun M3, Amital H4. BACKGROUND: The current mode of therapy for many patients with musculoskeletal pain is unsatisfactory. PURPOSE: We aimed to assess the impact of […]

Inflammation in intervertebral disc degeneration and regeneration – Full Text Article

Journal of the Royal Society Interface Maria Molinos, Catarina R. Almeida, Joana Caldeira, Carla Cunha, Raquel M. Gonçalves and Mário A. Barbosa Published:06 March 2015 https://doi.org/10.1098/rsif.2014.1191 Abstract Intervertebral disc (IVD) degeneration is one of the major causes of low back pain, a problem with a heavy economic burden, which has been increasing in prevalence as […]

Does stress affect the joints? Daily stressors, stress vulnerability, immune and HPA axis activity, and short-term disease and symptom fluctuations in rheumatoid arthritis

Ann Rheum Dis. 2014 Sep;73(9):1683-8. doi: 10.1136/annrheumdis-2012-203143. Epub 2013 Jul 9. Evers AW Abstract OBJECTIVES: Both stressors and stress vulnerability factors together with immune and hypothalamus-pituitary-adrenal (HPA) axis activity components have been considered to contribute to disease fluctuations of chronic inflammatory diseases, such as rheumatoid arthritis (RA). The aim of the present study was to […]

What’s the Link? Psoriasis and Heart Failure

PracticeUpdate.com Peter Libby MD In a recent article published in the European Journal of Heart Failure, Dr. Usman Khalid and colleagues interrogated the national database of Denmark to probe the link between psoriasis and the risk for heart failure.1 They followed a cohort for 14 years and identified psoriasis diagnoses by identifying individuals who received prescriptions for topical vitamin […]

Evaluation of TNF-α serum level in patients with recalcitrant multiple common warts, treated by lipid garlic extract

Dermatol Ther. 2014 Jun 9. doi: 10.1111/dth.12136. [Epub ahead of print] Evaluation of TNF-α serum level in patients with recalcitrant multiple common warts, treated by lipid garlic extract. Kenawy S1, Mohammed GF, Younes S, Elakhras AI. Abstract No universal consensus about optimal modality for treating the recalcitrant multiple common warts (RMCW). The objective of the […]

Irritable Eye Syndrome: Neuroimmune Mechanisms and Benefits of Selected Nutrients

Janos Feher, MD, PhD The Ocular Surface Volume 12, Issue 2 , Pages 134-145, April 2014 Abstract Previous studies showed comorbidity of some ocular, enteral, and affective symptoms comprising irritable eye syndrome. Aims of the present study were to learn more about the pathogenic mechanisms of this syndrome and to evaluate benefits of food supplements […]

Function of Auricular Point Acupressure in Inducing Changes in Inflammatory Cytokines During Chronic Low-Back Pain: A Pilot Study

To cite this article: Yeh Chao Hsing, Chien Lung Chang, Albers Kathryn M., Ren Dianxu, Huang Li Chun, Cheng Baoxia, Margolis Leah, Liu Richard, and Suen Lorna Kwai-Ping. Medical Acupuncture. February 2014, 26(1): 31-39. doi:10.1089/acu.2013.1015. Medical Axupuncture Published in Volume: 26 Issue 1: February 18, 2014 ABSTRACT Background: Auricular therapy is a promising treatment for […]

Are Your Food Allergies Making You Fat? VIDEO

by Mark Hyman, MD YOUR DIGESTIVE SYSTEM may be making you fat. It’s hard to believe—but very true. I want to explain the bugs in your digestive tract, why they upset your gut’s immune system, and how they just might be behind those extra pounds. I have observed this phenomenon in hundreds of patients. Recently, […]