Bone

SSRIs, Hypnotics Increase Fracture Risk

Medscape Medical News from: The American Society for Bone and Mineral Research (ASBMR) 2014 Story Source September 22, 2014 HOUSTON, Texas — Use of hypnotic medications for insomnia and use of selective serotonin reuptake inhibitors (SSRIs) are each associated with an increased risk for osteoporotic and hip fractures in older women and men, independent of other risk factors on […]

Higher Vitamin D in Menopause Linked to Big Reduction in Fracture

Nancy A. Melville September 15, 2014 HOUSTON — Women who maintain high vitamin-D levels throughout menopause have a more than 40% reduced risk for fracture during the transition than those whose levels are lower, according to new research presented here at the American Society for Bone and Mineral Research (ASBMR) 2014 annual meeting. “Women at midlife with higher […]

Leg-Stand Test Predicts Hip-Fracture Risk in Women

Nancy A. Melville September 13, 2014 HOUSTON — The inability to stand on 1 leg for 10 seconds or to squat down to reach the floor represent strong early predictors of hip fracture and mortality in postmenopausal women, according to a 15-year follow-up study presented here at the American Society for Bone and Mineral Research […]

Subtrochanteric femoral fracture – bisphosphonate related

Case contributed by: Dr Patsy Robertson Story Source Presentation: 78 year old female, thigh pain following a fall from a car Patient Data: Age: 78 Gender: Female Displaced subtrochanteric fracture of the left femur. The left hip is enlocated. Note is made of the widening of the lateral cortex proximal and distal to the fracture. […]

The acid-ash hypothesis revisited: a reassessment of the impact of dietary acidity on bone

J Bone Miner Metab. 2014 Sep;32(5):469-75. doi: 10.1007/s00774-014-0571-0. Epub 2014 Feb 21. Nicoll R1, McLaren Howard J. Abstract The acid-ash hypothesis states that when there are excess blood protons, bone is eroded to provide alkali to buffer the net acidity and maintain physiologic pH. There is concern that with the typical Western diet, we are […]

Dietary acid load, kidney function, osteoporosis, and risk of fractures in elderly men and women

Published: 16 September 2014 T. Jia, L. Byberg Osteoporosis International volume 26, pages563–570(2015) Abstract Summary Because kidney dysfunction reduces the ability to excrete dietary acid excess, we hypothesized that underlying kidney function may have confounded the mixed studies linking dietary acid load with the risk of osteoporosis and fractures in the community. In a relatively […]

Exposure to the sun could actually HALVE your chance of developing some forms of cancer

Exposure to the sun could actually HALVE your chance of developing some forms of cancer Sun exposure could potentially reduce the risks of ovarian, oesophageal and pancreatic cancers Not enough UV rays may cause children to develop rickets and ostemomalacia in adults Professor Neale is currently recruiting 25,000 Australians over 60 to participate in a […]

Significant link found between osteonecrosis and corticosteroids

Dilisio MF. Orthopedics. 2014. doi:10.3928/01477447-20140626-54. Story Source A low but statistically significant link was determined between osteonecrosis and short-term, low-dose oral corticosteroids, according to study findings. Researchers utilized a software platform to evaluate data from 24,533,880 patients who received either single or multiple methylprednisolone taper pack (MTP) prescriptions during a 12-year span. They then compared […]

Weak Bones Tied to Incident HF

MedPageToday Cardiovascular Published: Jul 10, 2014 By Todd Neale, Senior Staff Writer, MedPage Today Story Source Action Points Note that this observational cohort study demonstrated an association between lower bone mineral density in the heel and incident heart failure. Be aware that calcaneal ultrasound is not the standard tool for diagnosing osteoporosis; DXA scanning or, […]

Vegetarian diets and bone status 

American Journal of Clinical Nutrition, 06/19/2014  Clinical Article Story Source PubMed Reference Journal Reference Tucker KL –The study demonstrate that osteoporosis is a common chronic condition associated with progressive loss of bone mineral density (BMD) and compromised bone strength, with increasing risk of fracture over time. However, result suggest that attention to potential shortfall nutrients through the […]

Bone-cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies

Yuan XL, et al. Journal Osteoarthritis Cartilage. 2014 Jun 10. pii: S1063-4584(14)01102-9. doi: 10.1016/j.joca.2014.05.023. [Epub ahead of print] Affiliation Abstract Currently, osteoarthritis (OA) is considered a disease of the entire joint, which is not simply a process of wear and tear but rather abnormal remodelling and joint failure of an organ. The bone-cartilage interface is therefore […]

Sulfonylureas and TZDs May Up Fracture Risk in Diabetes

Medscape Medical News > Conference News Miriam E. Tucker June 15, 2014 SAN FRANCISCO — The oral diabetes drug classes of thiazolidinediones (TZDs/Brand Names) and sulfonylureas (Brand Names) both boost the risk for fractures compared with metformin, a large database analysis has found. The observational study confirms previous findings of increased fracture risk with TZDs but is the first […]

Obstructive Sleep Apnea and Osteoporosis

Obstructive Sleep Apnea and Osteoporosis: New Findings —A large population-based cohort study in Taiwan demonstrates an elevated risk of osteoporosis in individuals with obstructive sleep apnea. By Kevin O. Hwang, MD, MPH Reviewed by Vrunda Bhavsar Desai, MD, FACOG, Assistant Professor of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT […]

Association of low back pain, somatic dysfunction, and lumbar bone mineral density

Reproducibility of findings Snider KT, et al. J Am Osteopath Assoc. 2014 May;114(5):356-67. doi: 10.7556/jaoa.2014.073. Abstract CONTEXT: Somatic dysfunction as diagnosed by palpation should be associated with an objective measure. Bone mineral density (BMD) has been shown to be elevated in lumbar vertebrae with somatic dysfunction and in the lumbar region of individuals with chronic […]

Citing Fracture Risk, Watchdog Group Sues FDA to Force GERD Drug Warning

Published: Apr 30, 2014 By Elbert Chu The FDA failed to respond to a 2011 petition demanding strong warnings about proton pump inhibitors (PPIs), according to a Public Citizen’s lawsuit filed today. Public Citizen’s lawsuit seeks a ruling from the U.S. District Court of the District of Columbia that the FDA unlawfully withheld action, and calls for an […]

Uric Acid Linked to Fracture Risk

 — Older men with higher uric acid levels may be at increased risk for hip fracture, researchers reported here. by Kristina Fiore, Staff Writer, MedPage Today April 28, 2014 AS VEGAS — Older men with higher uric acid levels may be at increased risk for hip fracture, researchers reported here. In a prospective cohort study, […]

Obstructive Sleep Apnea May Increase Osteoporosis Risk

Jennifer Garcia April 16, 2014 Patients with obstructive sleep apnea (OSA) are more than twice as likely to develop osteoporosis as patients without OSA, even when adjusting for age, comorbid conditions, income, and geographic location, according to a population-based study in Taiwan. Results of this longitudinal study were published online April 15 in the Journal […]

More Fractures Seen When Vitamin D Is Consistently Low

Norra MacReady April 15, 2014 Prolonged low levels of vitamin D increase long-term fracture risk in elderly women, a new study confirms. Low serum vitamin D levels at baseline and at a 5-year follow-up examination were associated with a significantly increased incidence of hip fractures at a 10-year follow-up examination, lead author David Buchebner, PhD, […]

Doubt Over Role of Vitamin D, Even to Limit Fractures

Becky McCall April 03, 2014 Full Story New results from extensive analyses of observational and randomized clinical trials (RCTs) suggest that vitamin D given alone does not appear to increase bone-mineral density or reduce the risk for fractures or falls in older people, contrary to many previous reports. The research also signifies that a clear […]

Coronary microvascular endothelial dysfunction is an independent predictor of development of osteoporosis in postmenopausal women

Vascular Health and Risk Management » Volume 10 Authors Prasad M, Reriani M, Khosla S, Gössl M, Lennon R, Gulati R, Prasad A, Lerman L, Lerman A Received 5 March 2014 Accepted for publication 3 April 2014 Published 26 August 2014 Volume 2014:10 Pages 533—538 DOI https://doi.org/10.2147/VHRM.S63580 Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN, […]