Disc

The relationship between sagittal spinopelvic parameters and the degree of lumbar intervertebral disc degeneration in young adult patients with low-grade spondylolytic spondylolisthesis

Bone Joint J. 2013 Sep;95-B(9):1239-43. doi: 10.1302/0301-620X.95B9.31717. Oh YM, Eun JP. We investigated the relationship between spinopelvic parameters and disc degeneration in young adult patients with spondylolytic spondylolisthesis. A total of 229 men with a mean age of 21 years (18 to 26) with spondylolytic spondylolisthesis were identified. All radiological measurements, including pelvic incidence, sacral […]

Do intervertebral discs degenerate before they herniate, or after? – Full Text Article

The Bone & Joint Journal Vol. 95-B, No. 8 P. Lama, C. L. Le Maitre, P. Dolan, J. F. Tarlton, I. J. Harding, M. A. Adams Published Online:1 Aug 2013 https://doi.org/10.1302/0301-620X.95B8.31660 The belief that an intervertebral disc must degenerate before it can herniate has clinical and medicolegal significance, but lacks scientific validity. We hypothesised that […]

The Anatomy of Failure in Lumbar Disc Herniation

ISSLS Prize Winner: The Anatomy of Failure in Lumbar Disc Herniation: An In Vivo, Multimodal, Prospective Study of 181 Subjects Rajasekaran, S. PhD, MS, MCh, FRCS(Ed), FRCS(London), FACS; Bajaj, Nipun MS, FNB; Tubaki, Vijay MS; Kanna, Rishi M. MS, MRCS, FNB; Shetty, Ajoy Prasad MS, DNB Spine01 August 2013 Abstract Study Design. A prospective multimodal […]

Clinical findings and electrodiagnostic testing in 108 consecutive cases of lumbosacral radiculopathy due to herniated disc

Neurophysiol Clin. 2013 Oct;43(4):205-15. doi: 10.1016/j.neucli.2013.05.004. Epub 2013 Jun 20. Mondelli M, Aretini A, Arrigucci U, Ginanneschi F, Greco G, Sicurelli F. Abstract STUDY AIM: This prospective study aim to examine whether clinical findings and electrodiagnostic testing (EDX) in patients with lumbosacral monoradiculopathy due to herniated disc (HD) differ as a function of root involvement […]

Effects of degenerated intervertebral discs on intersegmental rotations, intradiscal pressures, and facet joint forces of the whole lumbar spine

September 1, 2013Volume 43, Issue 9, Pages 1234–1240 Effects of degenerated intervertebral discs on intersegmental rotations, intradiscal pressures, and facet joint forces of the whole lumbar spine Won Man Park, Kyungsoo Kim, Yoon Hyuk Kim October 26, 2012; Accepted: June 18, 2013 Abstract The effects of intervertebral disc (IVD) degeneration on biomechanics of the lumbar […]

Glucosamine Supplementation Demonstrates a Negative Effect on Intervertebral Disc Matrix in an Animal Model of Disc Degeneration

Jacobs, Lloydine MD Spine: 20 May 2013 – Volume 38 – Issue 12 – p 984–990 Abstract Study Design. Laboratory based controlled in vivo study. Objective. To determine the in vivo effects of oral glucosamine sulfate on intervertebral disc degeneration. Summary of Background Data. Although glucosamine has demonstrated beneficial effect in articular cartilage, clinical benefit […]

Symptomatic magnetic resonance imaging-confirmed lumbar disk herniation patients: a comparative effectiveness prospective observational study of 2 age- and sex-matched cohorts treated with either high-velocity, low-amplitude spinal manipulative therapy or imaging-guided lumbar nerve root injections

J Manipulative Physiol Ther. 2013 May;36(4):218-25. doi: 10.1016/j.jmpt.2013.04.005. Epub 2013 May 22. Peterson CK1, Leemann S, Lechmann M, Pfirrmann CW, Hodler J, Humphreys BK. Abstract OBJECTIVES: The purpose of this study was to compare self-reported pain and “improvement” of patients with symptomatic, magnetic resonance imaging-confirmed, lumbar disk herniations treated with either high-velocity, low-amplitude spinal manipulative […]

Body mass index is associated with lumbar disc degeneration in young Finnish males

The Study: Body mass index is associated with lumbar disc degeneration in young Finnish males: subsample of Northern Finland birth cohort study 1986 The Facts: a. The authors sought to determine if BMI (body mass index), smoking and activity level are associated to disc degeneration. b. They studied 558 young adults. c. At the mean […]

The molecular basis of intervertebral disc degeneration

The Spine Journal Volume 13, Issue 3, March 2013, Pages 318-330 Christopher K.Kepler MD https://doi.org/10.1016/j.spinee.2012.12.003 Abstract Background Intervertebral disc (IVD) degeneration remains a clinically important condition for which treatment is costly and relatively ineffective. The molecular basis of degenerative disc disease has been an intense focus of research recently, which has greatly increased our understanding […]

The Effect of Glucosamine Sulfate on the Proliferative Potential and Glycosaminoglycan Synthesis of Nucleus Pulposus Intervertebral Disc Cells

In addition, glycosaminoglycan synthesis stimulated by glucosamine provides a possible promising clinical role for treating disc degenerative disorders.

Abdominal Obesity and Lumbar Disc Degeneration

Takatalo J. PLoS One. 2013;8(2):e56244. doi: 10.1371/journal.pone.0056244. Epub 2013 Feb 13 Abstract PURPOSE: To evaluate whether midsagittal (abdominal) obesity in magnetic resonance imaging (MRI), waist circumference (WC) and body fat percentage are associated with lumbar disc degeneration in early adulthood. METHODS: We obtained the lumbar MRI (1.5-T scanner) of 325 females and 233 males at a […]

Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease

J Craniovertebr Junction Spine. 2013 Jan;4(1):16-20. doi: 10.4103/0974-8237.121619. Clinical correlation of magnetic resonance imaging with symptom complex in prolapsed intervertebral disc disease: A cross-sectional double blind analysis. Bajpai J1, Saini S1, Singh R1. Abstract INTRODUCTION: Low backache (LBA) is one of the most common problems and herniated lumbar disc is one of the most commonly […]

Inflammatory Mediators in Intervertebral Disk Degeneration and Discogenic Pain

Global Spine J 2013; 03(03): 175-184 Karin Wuertz Abstract Although degeneration of the intervertebral disk has historically been described as a misbalance between anabolic and catabolic factors, the role of inflammatory mediators has long been neglected. However, past research clearly indicates that inflammatory mediators such as interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor-α are […]

Cervical disc herniation presenting with neck pain and contralateral symptoms: a case report

Cervical disc herniation presenting with neck pain and contralateral symptoms: a case report Jacky T Yeung http://www.jmedicalcasereports.com/content/6/1/166 Journal of Medical Case Reports 2012, 6:166 doi:10.1186/1752-1947-6-166 Abstract Introduction Cervical disc herniation often results in neck and arm pain in patients as a result of direct impingement of nerve roots and associated inflammatory processes. The clinical presentation […]

The association of lumbar intervertebral disc degeneration on MRI with body mass index in overweight and obese adults

A population-based study Samartzis D, et al. Arthritis Rheum. 2012 May;64(5):1488-96. doi: 10.1002/art.33462. Comment in Arthritis Rheum. 2012 Dec;64(12):4163-4; author reply 4164-5. Abstract OBJECTIVE: To investigate the association of being overweight or obese with the presence, extent, and severity of lumbar disc degeneration on magnetic resonance imaging (MRI) in adults. METHODS: A population-based cross-sectional study […]

Inversion therapy in patients with pure single level lumbar discogenic disease: a pilot randomized trial

Disabil Rehabil. 2012;34(17):1473-80. doi: 10.3109/09638288.2011.647231. Epub 2012 Jan 23. K S Manjunath Prasad Abstract Purpose: Backache and sciatica due to protuberant disc disease is a major cause of lost working days and health expenditure. Surgery is a well-established option in the management flowchart. There is no strong evidence proving that traction for sciatica is effective. […]

Neck and back pain and intervertebral disc degeneration: Role of occupational factors

Practice points LBP affects between 14% and 80% of working-aged people, depending on case definition. Disc protrusion and disc degeneration, as determined by MRI, are strongly associated with LBP. Work-related factors, including heavy lifting and frequent bending and twisting, are associated with lumbar disc disease. Population studies of cervical pain and cervical disc disease have lagged behind […]

Yoga and disc degenerative disease in cervical and lumbar spine

Yoga and disc degenerative disease in cervical and lumbar spine: an MR imaging-based case control study. Authors Jeng CM1, Cheng TC, Kung CH, Hsu HC. Journal Eur Spine J. 2011 Mar;20(3):408-13. doi: 10.1007/s00586-010-1547-y. Epub 2010 Aug 15. Abstract The objective of the current study was to find out whether yoga practice was beneficial to the […]

Potential of Magnetic Resonance Imaging Findings to Refine Case Definition for Mechanical Low Back Pain in Epidemiological Studies

A Systematic Review Endean, Alison MBChB, MRCP Spine:  15 January 2011 – Volume 36 – Issue 2 – p 160–169 Abstract Study Design. Systematic review and meta-analysis. Objective. To assess how confidently low back pain (LBP) can be attributed to abnormalities on magnetic resonance imaging (MRI), and thereby explore the potential value of MRI abnormalities […]

An immunohistochemical study of mechanoreceptors in lumbar spine intervertebral discs

Dimitroulias A, et al. Citation J Clin Neurosci. 2010 Jun;17(6):742-5. doi: 10.1016/j.jocn.2009.09.032. Epub 2010 Mar 26. Abstract There are limited data concerning mechanoreceptors in normal human lumbar intervertebral discs. The aim of our study was to determine the types of mechanoreceptors in the two lower intervertebral discs in normal adult cadaveric donors and to review […]